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Fructose Can Enhance Fat Absorption In The Gut, Read It To Learn More

The new research stemmed from a 2019 study investigating the impact of HFCS on colorectal cancer. That study discovered a molecular mechanism through which fructose at once enhances tumor cell growth. So the subsequent logical find out about target was the impact fructose had on non-cancerous intestinal cells.



The first discovering in the new research was once that mice fed high-fructose diets were found to have villi up to forty percent longer than animals not fed fructose. Subsequent investigation printed mice with these longer villi won extra weight on a high-fat diet than mice fed a high-fat diet without introduced fructose.


Drilling down into the molecular mechanism at work, the researchers detected high levels of fructose-1-phosphate gathering in cells. Fructose-1-phosphate is a metabolite of fructose and it can boost the survival of villus cells. It is this mechanism, the researchers suggest, that is responsible for fructose promotion villi length, main to elevated fats absorption and weight gain.


Samuel Taylor, first creator on the new study, hypothesizes an evolutionary reason for animals creating this uncommon mechanism, announcing it makes sense for mammals to maximize fats absorption from fructose in overripe fruit.


“In mammals, especially hibernating mammals in temperate climates, you have fructose being very handy in the fall months when the fruit is ripe,” says Taylor. “Eating a lot of fructose may help these animals to take in and convert greater nutrients to fat, which they want to get through the winter.”


But the problem that arises in modern instances is one of overconsumption of fructose in forms of sweeteners such as high-fructose corn syrup. As senior writer Marcus DeSilva Goncalves explains, the trouble is simple, we now devour too lots fructose.


“Fructose itself is not harmful,” notes Goncalves. “It's a problem of overconsumption. Our our bodies were not designed to devour as much of it as we do.”


This is not the first find out about to shine a mild on the potential damage caused by immoderate fructose consumption. An influential 2019 study regarded at the influence of fructose on the liver and located it exerted novel metabolic effects on the organ, ensuing in larger accumulations of fat. This effect was once not seen with glucose.


More work wants to be carried out to confirm the findings of this new study in humans, however Goncalves says if these findings are validated in humans they may want to potentially lead to new methods for treating colorectal cancers and obesity.


“There are already drugs in medical trials for other functions that goal the enzyme accountable for producing fructose-1-phosphate,” says Goncalves. "We're hoping to locate a way to repurpose them to shrink the villi, reduce fats absorption, and perchance slow tumor growth.”


Originally published: New Atlas

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